Submitted by ja607 on
Title | Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | de Goede, OM, Nachun, DC, Ferraro, NM, Gloudemans, MJ, Rao, AS, Smail, C, Eulalio, TY, Aguet, F, Ng, B, Xu, J, Barbeira, AN, Castel, SE, Kim-Hellmuth, S, Park, YS, Scott, AJ, Strober, BJ, Brown, CD, Wen, X, Hall, IM, Battle, A, Lappalainen, T, Im, HKyung, Ardlie, KG, Mostafavi, S, Quertermous, T, Kirkegaard, K, Montgomery, SB |
Corporate Authors | GTEx Consortium |
Journal | Cell |
Volume | 184 |
Issue | 10 |
Pagination | 2633-2648.e19 |
Date Published | 2021 05 13 |
ISSN | 1097-4172 |
Keywords | Coronary Artery Disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Disease, Gene Expression Profiling, Genetic Variation, Humans, Inflammatory Bowel Diseases, Multifactorial Inheritance, Organ Specificity, Population, Quantitative Trait Loci, RNA, Long Noncoding, Transcriptome |
Abstract | Long non-coding RNA (lncRNA) genes have well-established and important impacts on molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a major challenge to identify the subset with disease or trait relevance. To systematically characterize these lncRNA genes, we used Genotype Tissue Expression (GTEx) project v8 genetic and multi-tissue transcriptomic data to profile the expression, genetic regulation, cellular contexts, and trait associations of 14,100 lncRNA genes across 49 tissues for 101 distinct complex genetic traits. Using these approaches, we identified 1,432 lncRNA gene-trait associations, 800 of which were not explained by stronger effects of neighboring protein-coding genes. This included associations between lncRNA quantitative trait loci and inflammatory bowel disease, type 1 and type 2 diabetes, and coronary artery disease, as well as rare variant associations to body mass index. |
DOI | 10.1016/j.cell.2021.03.050 |
Alternate Journal | Cell |
PubMed ID | 33864768 |
PubMed Central ID | PMC8651477 |
Grant List | R01 HL109512 / HL / NHLBI NIH HHS / United States U01 HG009431 / HG / NHGRI NIH HHS / United States R01 HG008150 / HG / NHGRI NIH HHS / United States R01 MH107666 / MH / NIMH NIH HHS / United States T32 NS105604 / NS / NINDS NIH HHS / United States R01 MH109905 / MH / NIMH NIH HHS / United States R01 MH106842 / MH / NIMH NIH HHS / United States UM1 HG008901 / HG / NHGRI NIH HHS / United States R01 GM124486 / GM / NIGMS NIH HHS / United States U01 HG009080 / HG / NHGRI NIH HHS / United States R01 HL134817 / HL / NHLBI NIH HHS / United States R01 MH125244 / MH / NIMH NIH HHS / United States R01 HL135313 / HL / NHLBI NIH HHS / United States R01 HL139478 / HL / NHLBI NIH HHS / United States R01 HL142015 / HL / NHLBI NIH HHS / United States K99 HG009916 / HG / NHGRI NIH HHS / United States T15 LM007033 / LM / NLM NIH HHS / United States R33 HL120757 / HL / NHLBI NIH HHS / United States R01 HL142028 / HL / NHLBI NIH HHS / United States R01 HG010067 / HG / NHGRI NIH HHS / United States R01 AG066490 / AG / NIA NIH HHS / United States R01 GM122924 / GM / NIGMS NIH HHS / United States U41 HG009494 / HG / NHGRI NIH HHS / United States R01 MH101822 / MH / NIMH NIH HHS / United States HHSN268201000029C / HL / NHLBI NIH HHS / United States R01 MH101814 / MH / NIMH NIH HHS / United States P30 DK020595 / DK / NIDDK NIH HHS / United States |