The NHGRI Genome Sequencing Program Analysis Centers (GSPAC) are a collaborative initiative that will undertake computational analyses of the data produced by the NHGRI Genome Sequencing Program to extract genomic and biological knowledge.

The goals of the GSPAC are to:

  • Undertake novel, investigator-initiated analyses that will cut across the individual GSP projects
  • Develop improved or novel analyses and methods for all non-automated aspects of characterizing sequence variants in the data, including:
    • Identification of associations between variants and disease phenotypes
    • Analyses using existing functional data to leverage associations and/or make functional inferences
    • Study design improvements
  • Work together with the other GSP components on cross-program analyses:
    • Defining the point at which a common disease/rare variant genome sequencing study is “comprehensive” or complete,
    • developing specifications for sample sets that could serve as common controls for common disease genome sequencing studies

The currently funded GSPACs are at Harvard University School of Public Health , Vanderbilt University School of Medicine , and a cross-institutional center at Icahn School of Medicine at Mount Sinai , Stanford School of Medicine , and University of California at San Francisco School of Pharmacy.

Date last modified: Fri, 09/18/2020 - 09:59