VEXOR: an integrative environment for prioritization of functional variants in fine-mapping analysis.

TitleVEXOR: an integrative environment for prioritization of functional variants in fine-mapping analysis.
Publication TypeJournal Article
Year of Publication2017
AuthorsLemaçon, A, Beauparlant, CJoly, Soucy, P, Allen, J, Easton, D, Kraft, P, Simard, J, Droit, A
JournalBioinformatics
Volume33
Issue9
Pagination1389-1391
Date Published2017 05 01
ISSN1367-4811
KeywordsGenome, Human, Genome-Wide Association Study, Genomics, Humans, Polymorphism, Genetic, Sequence Analysis, DNA, Software
Abstract

Motivation: The identification of the functional variants responsible for observed genome-wide association studies (GWAS) signals is one of the most challenging tasks of the post-GWAS research era. Several tools have been developed to annotate genetic variants by their genomic location and potential functional implications. Each of these tools has its own requirements and internal logic, which forces the user to become acquainted with each interface.

Results: From an awareness of the amount of work needed to analyze a single locus, we have built a flexible, versatile and easy-to-use web interface designed to help in prioritizing variants and predicting their potential functional implications. This interface acts as a single-point of entry linking association results with reference tools and relevant experiments.

Availability and Implementation: VEXOR is an integrative web application implemented through the Shiny framework and available at: http://romix.genome.ulaval.ca/vexor.

Contact: arnaud.droit@crchuq.ulaval.ca.

Supplementary information: Supplementary data are available at Bioinformatics online.

DOI10.1093/bioinformatics/btw826
Alternate JournalBioinformatics
PubMed ID28453673
PubMed Central IDPMC5860431
Grant ListR35 CA197449 / CA / NCI NIH HHS / United States
U01 HG009088 / HG / NHGRI NIH HHS / United States
GPH-129344 / / CIHR / Canada