|On Negative Heritability and Negative Estimates of Heritability.
|Year of Publication
|Steinsaltz, D, Dahl, A, Wachter, KW
We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of additive genetic variation. These may result from random noise acting on estimates of genuinely positive heritability, but we argue that they may also arise from misspecification of the standard additive mechanism that is supposed to justify the statistical procedure. Researchers should be open to the possibility that negative heritability estimates could reflect a real physical feature of the biological process from which the data were sampled.
|PubMed Central ID
|P30 AG012839 / AG / NIA NIH HHS / United States
U01 HG009080 / HG / NHGRI NIH HHS / United States
BB/S001824/1 / BB / Biotechnology and Biological Sciences Research Council / United Kingdom