A common loss-of-function variant is associated with lower vitamin B concentration in African Americans.

TitleA common loss-of-function variant is associated with lower vitamin B concentration in African Americans.
Publication TypeJournal Article
Year of Publication2018
AuthorsHu, Y, Raffield, LM, Polfus, LM, Moscati, A, Nadkarni, G, Preuss, MH, Zhong, X, Wei, Q, Rich, SS, Li, Y, Wilson, JG, Correa, A, Loos, RJF, Li, B, Auer, PL, Reiner, AP
Corporate AuthorsNHLBI Trans-Omics for Precision Medicine Consortium
JournalBlood
Volume131
Issue25
Pagination2859-2863
Date Published2018 06 21
ISSN1528-0020
KeywordsAfrican Americans, Female, Genome-Wide Association Study, Humans, Loss of Function Mutation, Male, Polymorphism, Single Nucleotide, Transcobalamins, Vitamin B 12, Vitamin B Deficiency
DOI10.1182/blood-2018-03-841023
Alternate JournalBlood
PubMed ID29764838
PubMed Central IDPMC6014360
Grant ListHHSN268201100037C / HL / NHLBI NIH HHS / United States
U01 HG007417 / HG / NHGRI NIH HHS / United States
R01 HL132947 / HL / NHLBI NIH HHS / United States
R01 HL130733 / HL / NHLBI NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
R01 HL129132 / HL / NHLBI NIH HHS / United States
U01 HG004603 / HG / NHGRI NIH HHS / United States
R01 DK110113 / DK / NIDDK NIH HHS / United States
HHSN268201300048C / HL / NHLBI NIH HHS / United States
R01 DK107786 / DK / NIDDK NIH HHS / United States
T32 HL129982 / HL / NHLBI NIH HHS / United States
HHSN268201300049C / HL / NHLBI NIH HHS / United States
R01 DK101855 / DK / NIDDK NIH HHS / United States
HHSN268201300047C / HL / NHLBI NIH HHS / United States
RC2 GM092618 / GM / NIGMS NIH HHS / United States
HHSN268201300050C / HL / NHLBI NIH HHS / United States
S10 OD020069 / OD / NIH HHS / United States
HHSN268201300046C / HL / NHLBI NIH HHS / United States
R01 HL117626 / HL / NHLBI NIH HHS / United States
U01 HG009086 / HG / NHGRI NIH HHS / United States
U54 GM115428 / GM / NIGMS NIH HHS / United States