%0 Journal Article %J Int J Equity Health %D 2020 %T Race, socioeconomic deprivation, and hospitalization for COVID-19 in English participants of a national biobank. %A Patel, Aniruddh P %A Paranjpe, Manish D %A Kathiresan, Nina P %A Rivas, Manuel A %A Khera, Amit V %K Adult %K Aged %K Biological Specimen Banks %K Continental Population Groups %K Coronavirus Infections %K COVID-19 %K Female %K Health Status Disparities %K Hospitalization %K Humans %K Male %K Middle Aged %K Pandemics %K Pneumonia, Viral %K Prospective Studies %K Socioeconomic Factors %K United Kingdom %X

Preliminary reports suggest that the Coronavirus Disease 2019 (COVID- 19) pandemic has led to disproportionate morbidity and mortality among historically disadvantaged populations. We investigate the racial and socioeconomic associations of COVID- 19 hospitalization among 418,794 participants of the UK Biobank, of whom 549 (0.13%) had been hospitalized. Both Black participants (odds ratio 3.7; 95%CI 2.5-5.3) and Asian participants (odds ratio 2.2; 95%CI 1.5-3.2) were at substantially increased risk as compared to White participants. We further observed a striking gradient in COVID- 19 hospitalization rates according to the Townsend Deprivation Index - a composite measure of socioeconomic deprivation - and household income. Adjusting for socioeconomic factors and cardiorespiratory comorbidities led to only modest attenuation of the increased risk in Black participants, adjusted odds ratio 2.4 (95%CI 1.5-3.7). These observations confirm and extend earlier preliminary and lay press reports of higher morbidity in non-White individuals in the context of a large population of participants in a national biobank. The extent to which this increased risk relates to variation in pre-existing comorbidities, differences in testing or hospitalization patterns, or additional disparities in social determinants of health warrants further study.

%B Int J Equity Health %V 19 %P 114 %8 2020 07 06 %G eng %N 1 %1 https://www.ncbi.nlm.nih.gov/pubmed/32631328?dopt=Abstract %R 10.1186/s12939-020-01227-y